Insights in Hodgkin Lymphoma angiogenesis

Christian Marinaccio; Beatrice Nico; Eugenio Maiorano; Giorgina Specchia; Domenico Ribatti

doi:10.1016/j.leukres.2014.05.023

Insights in Hodgkin Lymphoma angiogenesis

Leuk Res. 2014 Aug;38(8):857-61. doi: 10.1016/j.leukres.2014.05.023. Epub 2014 Jun 4.

Authors

Christian Marinaccio¹, Beatrice Nico¹, Eugenio Maiorano², Giorgina Specchia³, Domenico Ribatti⁴

Affiliations

¹ Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Bari, Italy.
² Department of Emergency and Transplantation, Pathology Section, University of Bari Medical School, Bari, Italy.
³ Department of Emergency and Transplantation, Hematology Section, University of Bari Medical School, Bari, Italy.
⁴ Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Bari, Italy; National Cancer Institute "Giovanni Paolo II", Bari, Italy. Electronic address: domenico.ribatti@uniba.it.

PMID: 24957412
DOI: 10.1016/j.leukres.2014.05.023

Abstract

Angiogenesis is a hallmark of tumor growth and progression in solid and hematological malignancies. Different cellular components of the tumor microenvironment such as macrophages, mast cells, circulating endothelial cells and angiogenic factors, including vascular endothelial growth factor and its receptors are involved in the maintenance of Hodgkin Lymphoma. In this review article, we highlight relevant literature focusing on the relationships between angiogenesis and Hodgkin Lymphoma as well as discussing anti-angiogenic treatments in this malignancy.

Keywords: Angiogenesis; Anti-angiogenesis; Hodgkin Lymphoma; Tumor microenvironment.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Angiogenesis Inhibitors / therapeutic use
Animals
Histone Deacetylase Inhibitors / therapeutic use
Hodgkin Disease / drug therapy
Hodgkin Disease / immunology
Hodgkin Disease / pathology*
Humans
Immunomodulation
Macrophages / physiology
Mast Cells / physiology
Neovascularization, Pathologic / drug therapy
Neovascularization, Pathologic / etiology*
Neovascularization, Pathologic / immunology
Vascular Endothelial Growth Factor A / antagonists & inhibitors
Vascular Endothelial Growth Factor A / immunology

Substances

Angiogenesis Inhibitors
Histone Deacetylase Inhibitors
VEGFA protein, human
Vascular Endothelial Growth Factor A