Abstract
The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was elaborated by a convergent asymmetric synthesis with 36% yield in ten steps.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cycloaddition Reaction / methods*
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Models, Molecular
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Molecular Docking Simulation
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Myeloid Cell Leukemia Sequence 1 Protein / antagonists & inhibitors
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Myeloid Cell Leukemia Sequence 1 Protein / metabolism*
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / pharmacology
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bcl-X Protein / antagonists & inhibitors
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bcl-X Protein / metabolism*
Substances
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MCL1 protein, human
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Myeloid Cell Leukemia Sequence 1 Protein
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Sesquiterpenes
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bcl-X Protein
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meiogynin A