ATP signaling in skeletal muscle: from fiber plasticity to regulation of metabolism

Exerc Sport Sci Rev. 2014 Jul;42(3):110-6. doi: 10.1249/JES.0000000000000017.

Abstract

Tetanic electrical stimulation releases adenosine triphosphate (ATP) from muscle fibers through pannexin-1 channels in a frequency-dependent manner; extracellular ATP activates signals that ultimately regulate gene expression and is able to increase glucose transport through activation of P2Y receptors, phosphatidylinositol 3-kinase, Akt, and AS160. We hypothesize that this mechanism is an important link between exercise and the regulation of muscle fiber plasticity and metabolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Biological Transport
  • Calcium Channels, L-Type / metabolism
  • Connexins / metabolism
  • Electric Stimulation
  • Exercise / physiology*
  • GTPase-Activating Proteins / metabolism
  • Gene Expression Regulation
  • Glucose / metabolism
  • Humans
  • Inositol 1,4,5-Trisphosphate / metabolism
  • Muscle Fibers, Skeletal / metabolism*
  • Nerve Tissue Proteins / metabolism
  • Nucleotides / metabolism
  • Phosphatidylinositol 3-Kinase / metabolism
  • Receptors, Purinergic P2 / metabolism
  • Signal Transduction

Substances

  • Calcium Channels, L-Type
  • Connexins
  • GTPase-Activating Proteins
  • Nerve Tissue Proteins
  • Nucleotides
  • PANX1 protein, human
  • Receptors, Purinergic P2
  • TBC1D4 protein, human
  • Inositol 1,4,5-Trisphosphate
  • Adenosine Triphosphate
  • Phosphatidylinositol 3-Kinase
  • Glucose