Endoscopic ultrasound-guided fine needle aspiration cytology and biopsy in the evaluation of lymphoma

Endosc Ultrasound. 2012 Apr;1(1):17-22. doi: 10.7178/eus.01.004.

Abstract

Accurate diagnosis and subtyping of lymphoma have important prognostic implications and are generally required for treatment planning. Histological assessment, immunophenotyping, and genetic studies are usually necessary. Endoscopic ultrasound guided-fine needle aspiration cytology (EUS-FNAC) is a minimally invasive technique widely used for the evaluation of deep-seated benign and malignant lesions. However, the value of cytological samples in lymphoma diagnosis is still a matter of debate. Endoscopic ultrasound guided-fine needle biopsy (EUS-FNAB) can provide tissue core samples that may help overcome the limitations of cytology. The aim of this review is to summarize the available literature regarding EUS-FNAC and EUS-FNAB for the diagnosis and subtyping of lymphoma. In addition, we discuss its usefulness in the management of primary extra-nodal lymphomas, as well as technical issues that may influence sample quality.

Keywords: biopsy; cytology; endoscopic ultrasound; fine needle aspiration; lymphoma.

Publication types

  • Review