Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer

Future Oncol. 2014 May;10(7):1187-202. doi: 10.2217/fon.13.263.

Abstract

Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed.

Patients & methods: Fifty-two GC and 23 control samples were included.

Results: GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033).

Conclusion: GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients.

Keywords: GDF15; MMP7; biomarkers; diagnostic; gastric cancer; metastasis; miR-200c; prognostic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers, Tumor / blood
  • Case-Control Studies
  • Disease-Free Survival
  • Female
  • Growth Differentiation Factor 15 / blood*
  • Humans
  • Male
  • Matrix Metalloproteinase 7 / blood*
  • MicroRNAs / blood*
  • Middle Aged
  • Prognosis
  • Stomach Neoplasms / blood*
  • Stomach Neoplasms / pathology

Substances

  • Biomarkers, Tumor
  • GDF15 protein, human
  • Growth Differentiation Factor 15
  • MIRN200 microRNA, human
  • MicroRNAs
  • MMP7 protein, human
  • Matrix Metalloproteinase 7