Overexpression of CDKN2B (p15INK4B) and altered global DNA methylation status in mesenchymal stem cells of high-risk myelodysplastic syndromes

Leukemia. 2014 Nov;28(11):2241-4. doi: 10.1038/leu.2014.197. Epub 2014 Jun 19.

Authors

A Poloni¹, G Maurizi¹, D Mattiucci¹, S Amatori², B Fogliardi², B Costantini¹, M Mariani¹, S Mancini¹, A Olivieri¹, M Fanelli², P Leoni¹

Affiliations

¹ Clinica di Ematologia, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy.
² Laboratorio di Patologia Molecolare 'PaoLa', Dipartimento di Scienze Biomolecolari, Università di Urbino 'Carlo Bo', Fano, Italy.

PMID: 24943834
DOI: 10.1038/leu.2014.197

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Cyclin-Dependent Kinase Inhibitor p15 / genetics*
DNA Methylation / physiology*
Female
Humans
Male
Mesenchymal Stem Cells / physiology*
Middle Aged
Myelodysplastic Syndromes / genetics*
Myelodysplastic Syndromes / physiopathology
Young Adult

Substances

CDKN2B protein, human
Cyclin-Dependent Kinase Inhibitor p15