Visualization of upconverting nanoparticles in strongly scattering media

E V Khaydukov; V A Semchishen; V N Seminogov; A V Nechaev; A V Zvyagin; V I Sokolov; A S Akhmanov; V Ya Panchenko

doi:10.1364/BOE.5.001952

Visualization of upconverting nanoparticles in strongly scattering media

Biomed Opt Express. 2014 May 28;5(6):1952-64. doi: 10.1364/BOE.5.001952. eCollection 2014 Jun 1.

Authors

E V Khaydukov¹, V A Semchishen¹, V N Seminogov¹, A V Nechaev², A V Zvyagin¹, V I Sokolov¹, A S Akhmanov¹, V Ya Panchenko¹

Affiliations

¹ Institute on Laser and Information Technologies of the Russian Academy of Sciences, City of Shatura, Moscow Region, Svyatoozerskaya ul. 1, 140700, Russia.
² Institute on Laser and Information Technologies of the Russian Academy of Sciences, City of Shatura, Moscow Region, Svyatoozerskaya ul. 1, 140700, Russia ; M.V. Lomonosov Moscow State University of Fine Chemical Technologies, Moscow, prospekt Vernadskogo 86, 119541, Russia.

Abstract

Optical visualization systems are needed in medical applications for determining the localization of deep-seated luminescent markers in biotissues. The spatial resolution of such systems is limited by the scattering of the tissues. We present a novel epi-luminescent technique, which allows a 1.8-fold increase in the lateral spatial resolution in determining the localization of markers lying deep in a scattering medium compared to the traditional visualization techniques. This goal is attained by using NaYF4:Yb(3+)Tm(3+)@NaYF4 core/shell nanoparticles and special optical fiber probe with combined channels for the excitation and detection of anti-Stokes luminescence signals.

Keywords: (110.0113) Imaging through turbid media; (160.4236) Nanomaterials.