Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis

Guangdie Yang; Junjun Chen; Fei Xu; Zhang Bao; Yake Yao; Jianying Zhou

doi:10.1371/journal.pone.0099962

Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis

PLoS One. 2014 Jun 17;9(6):e99962. doi: 10.1371/journal.pone.0099962. eCollection 2014.

Authors

Guangdie Yang¹, Junjun Chen¹, Fei Xu¹, Zhang Bao¹, Yake Yao¹, Jianying Zhou¹

Affiliation

¹ Department of Respiratory Diseases, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

Abstract

Objective: The purpose of this study was to explore the association between the TNF-α rs1800629 (also refers as -308G/A) polymorphism and asthma susceptibility.

Methods: We searched the Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.

Results: A total of 34 studies involving 5477 asthma patients and 5962 controls were included in present study. The results indicated that TNF-α rs1800629 polymorphism was significantly associated with asthma risk in a recessive genetic model (OR = 1.46, 95% CI 1.21-1.76, P<0.0001). Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = 1.48-4.12, P = 0.0005; OR = 1.83, 95% CI = 1.42-2.36, P<0.00001), but not East Asians and Caucasians. Furthermore, significant association also was observed in allergic asthma (OR = 1.51, 95% CI = 1.24-1.83, P<0.0001), adults and children (OR = 1.43, 95 CI% = 1.07-1.91, P = 0.02; OR = 1.57, 95% CI = 1.19-2.06, P = 0.001).

Conclusions: This meta-analysis suggested that the rs1800629 polymorphism in TNF-α was a risk factor for asthma.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Asthma / genetics*
Case-Control Studies
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Polymorphism, Single Nucleotide
Risk Factors
Tumor Necrosis Factor-alpha / genetics*

Substances

TNF protein, human
Tumor Necrosis Factor-alpha

Grants and funding

This research was funded by grants from the National Natural Science Foundation of China (No.81170038&No.81300009) and by grant from the Natural Science Foundation for the Youth of Zhejiang Province, China (No.Q13H010001). The funder (No.81170038) had a role in our study design, the funder (No.81300009) had a role in data collection and analysis, while the funder (No.Q13H010001) had a role in preparation of our manuscript.