Diarylheptanoids from green alder bark and their potential for DNA protection

Chem Biodivers. 2014 Jun;11(6):872-85. doi: 10.1002/cbdv.201300277.

Abstract

Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.

Keywords: Cytokinesis-block micronucleus (CBMN) assay; Green alder; Heptanoids, diaryl-.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alnus / chemistry*
  • Chromosome Aberrations / drug effects*
  • DNA / drug effects*
  • DNA Damage
  • Diarylheptanoids / chemistry
  • Diarylheptanoids / isolation & purification
  • Diarylheptanoids / pharmacology*
  • Dose-Response Relationship, Drug
  • Humans
  • Lymphocytes / drug effects
  • Micronucleus Tests
  • Molecular Structure
  • Plant Bark / chemistry*
  • Structure-Activity Relationship

Substances

  • Diarylheptanoids
  • DNA