NOTCH and PTEN in prostate cancer

Fred E Bertrand; James A McCubrey; C William Angus; Jennifer M Nutter; George Sigounas

doi:10.1016/j.jbior.2014.05.002

NOTCH and PTEN in prostate cancer

Adv Biol Regul. 2014 Sep:56:51-65. doi: 10.1016/j.jbior.2014.05.002. Epub 2014 May 22.

Authors

Fred E Bertrand¹, James A McCubrey², C William Angus³, Jennifer M Nutter³, George Sigounas³

Affiliations

¹ Department of Oncology, Brody School of Medicine at East Carolina University, USA. Electronic address: bertrandf@ecu.edu.
² Department of Microbiology & Immunology, Brody School of Medicine at East Carolina University, USA.
³ Department of Oncology, Brody School of Medicine at East Carolina University, USA.

PMID: 24933481
DOI: 10.1016/j.jbior.2014.05.002

Abstract

Over the past decade, our understanding of the role that Notch-signaling has in tumorigenesis has shifted from leukemogenesis into cancers of solid tumors. Emerging data suggests that in addition to direct effects mediated through the canonical Notch pathway, Notch may participate in epithelial tumor development through regulation of pathways such as PTEN/PI3K/Akt. Prostate cancer is a disease for which PTEN gene expression is especially essential. This review will summarize a role for Notch in prostate development and cancer with an emphasis on how the Notch pathway may intersect with PTEN/PI3K/Akt and mTOR signaling.

Keywords: EMT; Epithelial; Mesenchymal; Metabolism; Microenvironment; Tumor; mTOR.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Male
PTEN Phosphohydrolase / genetics
PTEN Phosphohydrolase / metabolism*
Prostatic Neoplasms / enzymology
Prostatic Neoplasms / genetics
Prostatic Neoplasms / metabolism*
Receptors, Notch / genetics
Receptors, Notch / metabolism*
Signal Transduction

Substances

Receptors, Notch
PTEN Phosphohydrolase
PTEN protein, human