Abstract
Norsampsones A-D (1-4), four new decarbonyl polycyclic polyprenylated acylphloroglucinols, together with a new biogenetically related compound hypersampsone M (5), were isolated from the aerial parts of Hypericum sampsonii. Norsampsones A-D featured an unprecedented carbon skeleton with the loss of C-2 carbonyl in the phloroglucinol ring. All structures were determined by extensive NMR spectroscopic methods, ECD calculation, and single-crystal X-ray diffraction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Hypericum / chemistry*
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Polycyclic Aromatic Hydrocarbons / chemistry
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Polycyclic Aromatic Hydrocarbons / isolation & purification*
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Polycyclic Aromatic Hydrocarbons / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Polycyclic Aromatic Hydrocarbons