Objective. The goal of this study was to compare four Sesotho-speaking clinical groups in South Africa concerning the manifestation of mental disorders. Methods. The participants were Sesotho speakers suffering from major depressive disorder, schizophrenia, anxiety disorders and substance abuse. The participants (N=407) were assessed and diagnosed by a multi-professional team. A clinical interview was then conducted with each participant and the symptomatology compared with the DSM-IV-TR criteria. Results. Differences among the four clinical groups were found regarding age, gender, marital status, substance abuse and aggressive behavior. Although the symptomatology of all four groups overlapped with that of their counterparts in Western cultures, some differences were noted. For example, delusions and hallucinations seem to be more prevalent in the Sesotho speakers with major depressive disorder and anxiety disorders than in Westernized groups. Traditional medicine remains the first treatment of choice for a significant number of the participants. It is recommended that traditional medicine should be incorporated into the national health system. Conclusion. In multicultural societies such as South Africa, further research regarding cultural differences in the clinical manifestation of mental disorders is urgently needed in order to make the necessary provision for cultural uniqueness.
Keywords: Africa; Clinical manifestation; Sesotho speakers; mental disorders; multicultural.