Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy

Mina Elahy; Swati Baindur-Hudson; Vinicius F Cruzat; Philip Newsholme; Crispin R Dass

doi:10.1530/JOE-14-0065

Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy

J Endocrinol. 2014 Sep;222(3):R129-39. doi: 10.1530/JOE-14-0065. Epub 2014 Jun 13.

Authors

Mina Elahy¹, Swati Baindur-Hudson¹, Vinicius F Cruzat², Philip Newsholme², Crispin R Dass³

Affiliations

¹ College of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, Australia.
² College of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, AustraliaCollege of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, Australia.
³ College of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, AustraliaCollege of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, Australia Crispin.Dass@curtin.edu.au.

PMID: 24928938
DOI: 10.1530/JOE-14-0065

Abstract

Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.

Keywords: PEDF; diabetes; oxidative stress; pericyte; redox balance; signal transduction.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antioxidants / metabolism
Apoptosis
Diabetic Neuropathies / etiology
Diabetic Neuropathies / metabolism*
Diabetic Neuropathies / prevention & control*
Diabetic Retinopathy / etiology
Diabetic Retinopathy / metabolism*
Diabetic Retinopathy / prevention & control*
Endothelial Cells / metabolism
Eye Proteins / metabolism*
Humans
Inflammation / etiology
Inflammation / metabolism
Inflammation / prevention & control
Models, Biological
NADP / metabolism
Nerve Growth Factors / metabolism*
Neuroprotective Agents / metabolism
Oxidative Stress
Pericytes / metabolism
Proto-Oncogene Proteins c-bcl-2 / metabolism
Reactive Oxygen Species / metabolism*
Serpins / metabolism*
Signal Transduction
bcl-2-Associated X Protein / metabolism

Substances

Antioxidants
BAX protein, human
Eye Proteins
Nerve Growth Factors
Neuroprotective Agents
Proto-Oncogene Proteins c-bcl-2
Reactive Oxygen Species
Serpins
bcl-2-Associated X Protein
pigment epithelium-derived factor
NADP