The effects of 3 weeks of rTMS treatment on P200 amplitude in patients with depression

Kyung Mook Choi; Kyoung-Mi Jang; Kuk In Jang; Yoo Hyun Um; Myung-Sun Kim; Do-Won Kim; Dongkyoo Shin; Jeong-Ho Chae

doi:10.1016/j.neulet.2014.06.003

The effects of 3 weeks of rTMS treatment on P200 amplitude in patients with depression

Neurosci Lett. 2014 Aug 8:577:22-7. doi: 10.1016/j.neulet.2014.06.003. Epub 2014 Jun 10.

Authors

Kyung Mook Choi¹, Kyoung-Mi Jang², Kuk In Jang³, Yoo Hyun Um⁴, Myung-Sun Kim², Do-Won Kim⁵, Dongkyoo Shin⁶, Jeong-Ho Chae⁷

Affiliations

¹ Department of Biomedical Science, Seoul, South Korea; Department of Psychiatry, Seoul St. Mary's Hospital, Seoul, South Korea; Institute of Biomedical Industry, The Catholic University of Korea, College of Medicine, Seoul, South Korea.
² Department of Psychology, Sungshin Women's University, Seoul, South Korea.
³ Institute of Biomedical Industry, The Catholic University of Korea, College of Medicine, Seoul, South Korea.
⁴ Department of Psychiatry, Seoul St. Mary's Hospital, Seoul, South Korea.
⁵ Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.
⁶ Department of Computer Engineering, Sejong University, Seoul, South Korea.
⁷ Department of Biomedical Science, Seoul, South Korea; Department of Psychiatry, Seoul St. Mary's Hospital, Seoul, South Korea; Institute of Biomedical Industry, The Catholic University of Korea, College of Medicine, Seoul, South Korea. Electronic address: alberto@catholic.ac.kr.

PMID: 24928222
DOI: 10.1016/j.neulet.2014.06.003

Abstract

Previous studies have reported that repetitive transcranial magnetic stimulation (rTMS) induces neuronal plasticity in the brain. Although event-related potential (ERP) is an exploration tool, the rTMS effects on ERPs in patients with major depression have not been fully explored. We demonstrated that rTMS treatment induces changes in brain function in patients with medication-resistant major depression using the ERP. Eighteen patients with medication-resistant major depression (five males and 13 females) participated in this study. The patients received rTMS treatment for 3 weeks. All patients completed clinical scales, including the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Scale (HAM-A), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (SAI, TAI), Ruminative Response Scale, Emotion Regulation Questionnaire, and Cognitive Emotion Regulation Questionnaire (CERQ), as well as the ERP auditory oddball task, at their first visit (baseline) and at the 3-week visit (3-weeks). The HAM-D, HAM-A, BDI, SAI, and "blaming others" scale of the CERQ decreased significantly after rTMS treatment. In ERP auditory oddball task, when FP1, FP2, FZ, FCZ, CZ, and PZ channels were analyzed, P200 amplitudes showed a main effect for time of measurement and increased after 3 weeks of rTMS treatment. Standardized low-resolution brain electromagnetic tomography showed significant activation in the left middle frontal gyrus by 3 weeks of rTMS treatment. The results suggest that relatively longer rTMS treatment induces changes in brain function in patients with medication-resistant major depression, which can be identified using ERP.

Keywords: Depression; ERP; rTMS; sLORETA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Depressive Disorder, Major / physiopathology*
Depressive Disorder, Major / therapy
Electroencephalography
Evoked Potentials*
Female
Humans
Male
Middle Aged
Transcranial Magnetic Stimulation*
Young Adult