Tumor metastasis inhibition by imaging-guided photothermal therapy with single-walled carbon nanotubes

Chao Liang; Shuo Diao; Chao Wang; Hua Gong; Teng Liu; Guosong Hong; Xiaoze Shi; Hongjie Dai; Zhuang Liu

doi:10.1002/adma.201401825

Tumor metastasis inhibition by imaging-guided photothermal therapy with single-walled carbon nanotubes

Adv Mater. 2014 Aug 27;26(32):5646-52. doi: 10.1002/adma.201401825. Epub 2014 Jun 13.

Authors

Chao Liang¹, Shuo Diao, Chao Wang, Hua Gong, Teng Liu, Guosong Hong, Xiaoze Shi, Hongjie Dai, Zhuang Liu

Affiliation

¹ Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou, Nano Science and Technology, Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215123, P.R. China.

PMID: 24924258
DOI: 10.1002/adma.201401825

Abstract

Multi-modal imaging guided photothermal therapy with single-walled carbon nanotubes affords effective destruction of primary tumors together with cancer cells in sentinel lymph nodes. This results in remarkably prolonged mouse survival compared to mice treated by elimination of only the primary tumor by either surgery or conventional photothermal therapy.

Keywords: biomaterials; photothermal therapy; single-walled carbon nanotubes; tumor metastasis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Combined Modality Therapy
Disease Models, Animal
Female
Hyperthermia, Induced / methods*
Infrared Rays
Lung Neoplasms / pathology
Lung Neoplasms / prevention & control
Lung Neoplasms / secondary
Lymph Nodes / pathology*
Lymphatic Metastasis / pathology
Lymphatic Metastasis / prevention & control*
Mammary Neoplasms, Animal
Mice
Mice, Inbred BALB C
Nanotubes, Carbon*
Neoplasms, Experimental / pathology
Neoplasms, Experimental / therapy*
Phototherapy / methods*
Random Allocation
Survival Analysis

Substances

Nanotubes, Carbon