EndoFLIP system for the intraoperative evaluation of peroral endoscopic myotomy

Pietro Familiari; Giovanni Gigante; Michele Marchese; Ivo Boskoski; Vincenzo Bove; Andrea Tringali; Vincenzo Perri; Graziano Onder; Guido Costamagna

doi:10.1177/2050640614521193

EndoFLIP system for the intraoperative evaluation of peroral endoscopic myotomy

United European Gastroenterol J. 2014 Apr;2(2):77-83. doi: 10.1177/2050640614521193.

Authors

Pietro Familiari¹, Giovanni Gigante¹, Michele Marchese¹, Ivo Boskoski¹, Vincenzo Bove¹, Andrea Tringali¹, Vincenzo Perri¹, Graziano Onder², Guido Costamagna¹

Affiliations

¹ Digestive Endoscopy Unit, Gemelli University Hospital, Università Cattolica del Sacro Cuore, Rome, Italy.
² Department of Geriatrics, Gemelli University Hospital, Università Cattolica del Sacro Cuore, Rome, Italy.

Abstract

Background: Peroral endoscopic myotomy (POEM) has been recently introduced in clinical practice for the treatment of achalasia. The endoluminal functional lumen imaging probe (EndoFLIP) system) uses impedance planimetry for the real-time measurement of the diameter of the oesophago-gastric junction.

Objective: The aim of this study is to prospectively evaluate the effect of POEM on the oesophago-gastric junction using EndoFLIP.

Methods: All the patients who underwent POEM in a single centre between April and July 2013 were enrolled in the study. EndoFLIP was used intraoperatively, immediately before and after POEM. During follow-up patients underwent oesophagogastroduodenoscopy, oesophageal pH monitoring and manometry. Clinical outcomes were compared with the diameter of the oesophago-gastric junction after POEM.

Results: In total, 23 patients (12 males, mean age 51.7 years) were enrolled, and 21 underwent POEM successfully. Preoperative mean basal lower oesophageal sphincter pressure was 42.1 mmHg (±17.6). Before POEM, the mean oesophago-gastric junction diameter and cross-sectional area were 6.3 mm (±1.8) and 32.9 mm(2) (±23.1), respectively. After treatment, the mean diameter and cross-sectional area of the oesophago-gastric junction were 11.3 mm (±1.7 SD) and 102.38 mm(2) (±28.2 SD), respectively. No complications occurred during a mean follow-up of 5 months. Median post-operative Eckardt score was 1. Three patients (14.3%) referred heartburn. Follow-up studies revealed gastro-oesophageal reflux disease (GORD) in 57.1% of patients and oesophagitis in 33.3%. No correlations were observed between the diameter of oesophago-gastric junction after POEM and symptoms relief, GORD incidence and lower oesophageal sphincter pressure.

Conclusions: The diameter of oesophago-gastric junction substantially increases after POEM. EndoFLIP is a reliable method for the intraoperative evaluation of oesophago-gastric junction diameter. However, the real usefulness of this technology after POEM remains controversial.

Keywords: Achalasia; EndoFLIP; endoscopy; oesophageal manometry; oesophago-gastric junction; oesophagus; peroral endoscopic myotomy.