Cytotoxicity of compounds from the fruits of Derris indica against cholangiocarcinoma and HepG2 cell lines

Phatharapoll Decharchoochart; Jittra Suthiwong; Papavee Samatiwat; Veerapol Kukongviriyapan; Chavi Yenjai

doi:10.1007/s11418-014-0851-y

Cytotoxicity of compounds from the fruits of Derris indica against cholangiocarcinoma and HepG2 cell lines

J Nat Med. 2014 Oct;68(4):730-6. doi: 10.1007/s11418-014-0851-y. Epub 2014 Jun 10.

Authors

Phatharapoll Decharchoochart¹, Jittra Suthiwong, Papavee Samatiwat, Veerapol Kukongviriyapan, Chavi Yenjai

Affiliation

¹ Natural Products Research Unit, Department of Chemistry, Faculty of Science, Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, 40002, Thailand.

PMID: 24913971
DOI: 10.1007/s11418-014-0851-y

Abstract

Two new compounds, derrivanone (1) and derrischalcone (2), were isolated from the crude hexane extract of the fruits of Derris indica. In addition, 14 known compounds were isolated from the fruits of this plant. Chalcones 2-4 showed strong cytotoxicity against cholangiocarcinoma cell line (M156) and human hepatoma HepG2 cells. In addition, flavanones 15 and 16 exhibited potent and high cytotoxic efficacy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / therapeutic use
Antineoplastic Agents / toxicity*
Bile Duct Neoplasms / drug therapy
Bile Ducts, Intrahepatic
Cell Line, Tumor
Chalcones / chemistry
Cholangiocarcinoma / drug therapy
Derris / chemistry*
Flavanones / chemistry
Flavanones / toxicity
Fruit / chemistry
Hep G2 Cells
Humans
Plant Extracts / chemistry

Substances

Antineoplastic Agents
Chalcones
Flavanones
Plant Extracts
derrischalcone
derrivanone