Abstract
Six new highly oxygenated chromene derivatives, oxirapentyns F-K (2-7), one new polyketide (8), one new benzofurane (9), and two known cyclodepsipeptides, isoisariin B and isaridin E, were isolated from the lipophilic extract of the marine-derived fungus Isaria felina KMM 4639. The structures of compounds 2-9 were determined using spectroscopic methods. The relative configurations of compounds 2-7 were established through a combination of NOE data and spin coupling constants, and these results were confirmed by X-ray crystallographic analysis of 4. The absolute structures of all oxirapentyns were assumed based on their biogenetic relationship and confirmed using the modified Mosher's method on 2 and 7. Isariketide (8) showed moderate cytotoxicity toward HL-60 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry
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Alkynes / isolation & purification*
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Alkynes / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification*
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Benzopyrans / pharmacology
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Cell Survival / drug effects
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Crystallography, X-Ray
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Depsipeptides / chemistry
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Depsipeptides / isolation & purification*
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Drug Screening Assays, Antitumor
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Geologic Sediments / chemistry*
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HL-60 Cells
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Humans
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Hypocreales / chemistry*
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Marine Biology
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Microbial Sensitivity Tests
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oceans and Seas
Substances
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Alkynes
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Antineoplastic Agents
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Benzopyrans
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Depsipeptides
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oxirapentyn