Drug delivery property, bactericidal property and cytocompatibility of magnetic mesoporous bioactive glass

Yi-Zhuo Liu; Yang Li; Xi-Bin Yu; Li-Na Liu; Zhen-An Zhu; Ya-Ping Guo

doi:10.1016/j.msec.2014.04.037

Drug delivery property, bactericidal property and cytocompatibility of magnetic mesoporous bioactive glass

Mater Sci Eng C Mater Biol Appl. 2014 Aug 1:41:196-205. doi: 10.1016/j.msec.2014.04.037. Epub 2014 Apr 26.

Authors

Yi-Zhuo Liu¹, Yang Li², Xi-Bin Yu¹, Li-Na Liu², Zhen-An Zhu³, Ya-Ping Guo⁴

Affiliations

¹ The Education Ministry Key Lab of Resource Chemistry, Shanghai Normal University, Shanghai 200234, PR China; Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, PR China.
² Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China.
³ Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China. Electronic address: zhuzhenan2006@126.com.
⁴ The Education Ministry Key Lab of Resource Chemistry, Shanghai Normal University, Shanghai 200234, PR China; Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, PR China. Electronic address: ypguo@shnu.edu.cn.

PMID: 24907752
DOI: 10.1016/j.msec.2014.04.037

Abstract

A multifunctional magnetic mesoporous bioactive glass (MMBG) has been widely used for a drug delivery system, but its biological properties have been rarely reported. Herein, the effects of mesopores and Fe3O4 nanoparticles on drug loading-release property, bactericidal property and biocompatibility have been investigated by using mesoporous bioactive glass (MBG) and non-mesoporous bioactive glass (NBG) as control samples. Both MMBG and MBG have better drug loading efficiency than NBG because they possess ordered mesoporous channels, big specific surface areas and high pore volumes. As compared with MBG, the Fe3O4 nanoparticles in MMBG not only provide magnetic property, but also improve sustained drug release property. For gentamicin-loaded MMBG (Gent-MMBG), the sustained release of gentamicin and the Fe3O4 nanoparticles minimize bacterial adhesion significantly and prevent biofilm formation against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis). Moreover, the magnetic Fe3O4 nanoparticles in MMBG can promote crucial cell functions such as cell adhesion, spreading and proliferation. The excellent biocompatibility and drug delivery property of MMBG suggest that Gent-MMBG has great potentials for treatment of implant-associated infections.

Keywords: Bactericidal property; Biocompatibility; Drug delivery system; Magnetic property; Mesoporous bioactive glass.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Biocompatible Materials / chemistry*
Biocompatible Materials / metabolism
Drug Carriers / chemistry*
Ferrosoferric Oxide / chemistry
Gentamicins / chemistry
Gentamicins / pharmacology
Glass / chemistry*
Magnetics*
Magnetite Nanoparticles / chemistry
Porosity
Staphylococcus aureus / drug effects
Staphylococcus epidermidis / drug effects

Substances

Anti-Bacterial Agents
Biocompatible Materials
Drug Carriers
Gentamicins
Magnetite Nanoparticles
Ferrosoferric Oxide