A step-up test procedure to find the minimum effective dose

Weizhen Wang; Jianan Peng

doi:10.1080/10543406.2014.920854

A step-up test procedure to find the minimum effective dose

J Biopharm Stat. 2015;25(3):525-38. doi: 10.1080/10543406.2014.920854.

Authors

Weizhen Wang¹, Jianan Peng

Affiliation

¹ a Department of Mathematics and Statistics , Wright State University , Dayton , Ohio , USA.

PMID: 24905396
DOI: 10.1080/10543406.2014.920854

Abstract

It is of great interest to find the minimum effective dose (MED) in dose-response studies. A sequence of decreasing null hypotheses to find the MED is formulated under the assumption of nondecreasing dose response means. A step-up multiple test procedure that controls the familywise error rate (FWER) is constructed based on the maximum likelihood estimators for the monotone normal means. When the MED is equal to one, the proposed test is uniformly more powerful than Hsu and Berger's test (1999). Also, a simulation study shows a substantial power improvement for the proposed test over four competitors. Three R-codes are provided in Supplemental Materials for this article. Go to the publishers online edition of Journal of Biopharmaceutical Statistics to view the files.

Keywords: Closed test method; Familywise error rate; Pooled-adjacent-violator algorithm; Step-up tests.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biometry / methods*
Computer Simulation
Data Interpretation, Statistical*
Dose-Response Relationship, Drug*
Likelihood Functions
Sample Size
Statistical Distributions
Stochastic Processes