Potent cytotoxic peptides from the Australian marine sponge Pipestela candelabra

Trong D Tran; Ngoc B Pham; Gregory A Fechner; John N A Hooper; Ronald J Quinn

doi:10.3390/md12063399

Potent cytotoxic peptides from the Australian marine sponge Pipestela candelabra

Mar Drugs. 2014 Jun 4;12(6):3399-415. doi: 10.3390/md12063399.

Authors

Trong D Tran¹, Ngoc B Pham², Gregory A Fechner³, John N A Hooper⁴, Ronald J Quinn⁵

Affiliations

¹ Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia. trong.tran@griffithuni.edu.au.
² Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia. n.pham@griffith.edu.au.
³ Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia. gregfeq@gmail.com.
⁴ Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia. john.hooper@qm.qld.gov.au.
⁵ Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia. r.quinn@griffith.edu.au.

Abstract

Two consecutive prefractionated fractions of the Australian marine sponge extract, Pipestela candelabra, were identified to be selectively active on the human prostate cancer cells (PC3) compared to the human neonatal foreskin fibroblast non-cancer cells (NFF). Twelve secondary metabolites were isolated in which four compounds are new small peptides. Their structures were characterized by spectroscopic and chemical analysis. These compounds inhibited selectively the growth of prostate cancer cells with IC50 values in the picomolar to sub-micromolar range. Structure-activity relationship of these compounds is discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Australia
Cell Line, Tumor
Fibroblasts / drug effects
Fibroblasts / metabolism
Humans
Infant, Newborn
Inhibitory Concentration 50
Male
Penis / cytology
Peptides / chemistry
Peptides / isolation & purification
Peptides / pharmacology*
Porifera / metabolism*
Prostatic Neoplasms / drug therapy*
Prostatic Neoplasms / pathology
Spectrum Analysis
Structure-Activity Relationship

Substances

Antineoplastic Agents
Peptides