Malignant rhabdoid tumor of the liver presented with initial tumor rupture

Denis Kachanov; Margarita Teleshova; Eduard Kim; Konstantin Dobrenkov; Roman Moiseenko; Anastasya Usychkina; Andrey Filin; Alexey Semenkov; Anna Mitrofanova; Dmitry Konovalov; Tatyana Shamanskaya; Galina Novichkova; Svetlana Varfolomeeva

doi:10.1016/j.cancergen.2014.04.006

Malignant rhabdoid tumor of the liver presented with initial tumor rupture

Cancer Genet. 2014 Sep;207(9):412-4. doi: 10.1016/j.cancergen.2014.04.006. Epub 2014 Apr 21.

Affiliations

¹ Department of Clinical Oncology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation. Electronic address: kachanov78@gmail.com.
² Department of Clinical Oncology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation.
³ Department of Liver Transplantation, acad. B.V. Petrovsky Russian Surgery Research Center, Moscow, Russian Federation.
⁴ Department of Pathology, Federal Scientific and Clinical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russian Federation.

PMID: 24894493
DOI: 10.1016/j.cancergen.2014.04.006

Abstract

Malignant rhabdoid tumor (MRT) of the liver is a rare, highly aggressive tumor of early childhood. We report a 6-month-old boy who was diagnosed with MRT of the liver and presented with spontaneous tumor rupture. The patient underwent intensified chemotherapy and a radical surgical procedure. Twenty four months from the time of the diagnosis, he is alive without evidence of disease. This is the second report of prolonged survival after initial rupture of hepatic MRT.

Keywords: Malignant rhabdoid tumor; chemotherapy; liver; tumor rupture.

Publication types

Case Reports

MeSH terms

Antineoplastic Agents / therapeutic use
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Chromosomal Proteins, Non-Histone / genetics
DNA-Binding Proteins / genetics
Humans
Infant
Liver / pathology
Liver Neoplasms / drug therapy*
Liver Neoplasms / genetics
Liver Neoplasms / pathology*
Male
Rhabdoid Tumor / drug therapy*
Rhabdoid Tumor / genetics
Rhabdoid Tumor / pathology*
Rupture
SMARCB1 Protein
Transcription Factors / genetics

Substances

Antineoplastic Agents
Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
SMARCB1 Protein
SMARCB1 protein, human
Transcription Factors