Synergistic acceleration in the osteogenesis of human mesenchymal stem cells by graphene oxide-calcium phosphate nanocomposites

Chem Commun (Camb). 2014 Aug 11;50(62):8484-7. doi: 10.1039/c4cc02442g.

Abstract

Nanocomposites consisting of oblong ultrathin plate shaped calcium phosphate nanoparticles and graphene oxide microflakes were synthesized and have demonstrated markedly synergistic effect in accelerating stem cell differentiation to osteoblasts.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Calcium Phosphates / pharmacology*
  • Cell Differentiation / drug effects
  • Graphite / pharmacology*
  • Humans
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / physiology*
  • Microscopy, Electron, Transmission
  • Microscopy, Fluorescence
  • Nanocomposites / chemistry*
  • Nanocomposites / ultrastructure
  • Osteoblasts / cytology*
  • Osteogenesis / physiology*
  • Regenerative Medicine / methods

Substances

  • Calcium Phosphates
  • Graphite
  • calcium phosphate