Abstract
The direct fluorination reaction of acetophenone using iodosylarenes and TEA·5HF was conducted under mild conditions except for use of a HF reagent. The fluorination reaction was applied to acetophenone derivatives, acetonaphthones, benzyl phenyl ketone, propiophenone, butyrophenone, 1-indanone, and phenacyl chloride, giving selectively the corresponding α-fluoroketone derivatives in good yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetophenones / chemical synthesis*
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Acetophenones / chemistry
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Ethylamines / chemistry*
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Halogenation
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Hydrocarbons, Fluorinated / chemistry*
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Indicators and Reagents / chemistry
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Iodine / chemistry*
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Molecular Structure
Substances
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Acetophenones
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Ethylamines
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Hydrocarbons, Fluorinated
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Indicators and Reagents
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Iodine
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acetophenone
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triethylamine