Abstract
We observed that murine macrophages showed greater activation and increased interleukin 6 (IL-6), IL-12p40, and interferon gamma (IFN-γ) production during Neospora caninum infection. Many macrophages migrated to the site of infection. Furthermore, macrophage-depleted mice exhibited increased sensitivity to N. caninum infection. This study indicates that macrophages are required for achieving protective immunity against N. caninum.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology
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Antigens, Differentiation / biosynthesis
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B7-1 Antigen / biosynthesis
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B7-2 Antigen / biosynthesis
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CD11b Antigen / metabolism
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CD4-Positive T-Lymphocytes / immunology*
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CD40 Antigens / biosynthesis
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Cells, Cultured
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Coccidiosis / immunology*
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Coccidiosis / parasitology
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Interferon-gamma / biosynthesis
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Interleukin-12 Subunit p40 / biosynthesis
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Interleukin-6 / biosynthesis
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Macrophage Activation / immunology
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Macrophages / immunology*
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Macrophages / parasitology
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Mice
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Mice, Inbred C57BL
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Neospora / immunology*
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Antibodies, Monoclonal
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Antigens, Differentiation
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B7-1 Antigen
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B7-2 Antigen
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CD11b Antigen
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CD40 Antigens
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Cd86 protein, mouse
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Interleukin-12 Subunit p40
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Interleukin-6
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monocyte-macrophage differentiation antigen
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Interferon-gamma