Synthesis, properties and prodrug potential of 2-methyl-2-oxy- and 2-methyl-2-thio-4H-1,3-benzodioxin-4-ones

Acta Chem Scand (Cph). 1989 Mar;43(3):213-21. doi: 10.3891/acta.chem.scand.43-0213.

Abstract

The fifty-four known title compounds are fully documented and their chemical and biological properties discussed in detail. Special attention is devoted to their potential as aspirin and salicylic acid prodrugs, respectively.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Aspirin / analogs & derivatives*
  • Benzyl Alcohols / chemical synthesis*
  • Benzyl Alcohols / chemistry
  • Benzyl Alcohols / pharmacology
  • Dioxins / chemical synthesis*
  • Dioxins / chemistry
  • Dioxins / pharmacology
  • Hydrolysis
  • Models, Molecular
  • Molecular Structure
  • Prodrugs / chemical synthesis*
  • Prodrugs / chemistry
  • Prodrugs / pharmacology
  • Salicylates*
  • Salicylic Acid

Substances

  • Benzyl Alcohols
  • Dioxins
  • Prodrugs
  • Salicylates
  • Salicylic Acid
  • Aspirin