Effect of single tablet of fixed-dose amlodipine and atorvastatin on blood pressure/lipid control, oxidative stress, and medication adherence in type 2 diabetic patients

Masami Tanaka; Risa Nishimura; Takeshi Nishimura; Toshihide Kawai; Shu Meguro; Junichiro Irie; Yoshifumi Saisho; Hiroshi Itoh

doi:10.1186/1758-5996-6-56

Effect of single tablet of fixed-dose amlodipine and atorvastatin on blood pressure/lipid control, oxidative stress, and medication adherence in type 2 diabetic patients

Diabetol Metab Syndr. 2014 May 18:6:56. doi: 10.1186/1758-5996-6-56. eCollection 2014.

Authors

Masami Tanaka¹, Risa Nishimura¹, Takeshi Nishimura¹, Toshihide Kawai¹, Shu Meguro¹, Junichiro Irie¹, Yoshifumi Saisho¹, Hiroshi Itoh¹

Affiliation

¹ Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Abstract

Background: Oxidized low-density lipoprotein (LDL) plays central roles in the formation and progression of atherosclerotic lesions. Malondialdehyde (MDA)-modified LDL (MDA-LDL) is speculated to be generated as a result of oxidative stress in the human body. Because both amlodipine and atorvastatin have been reported to reduce oxidative stress, it is expected that both drugs would have a favorable influence to reduce oxidative stress.

Objective: The objective of this study was to investigate the effects of a single pill of amlodipine (5 mg)/atorvastatin (10 mg) on oxidative stress, blood pressure/lipid control and adherence to medication in patients with type 2 diabetes.

Methods: This combination tablet was administered to 29 patients (16 male), and MDA-LDL, blood pressure, lipid profile, renal/liver function, CPK, hs-CRP, adiponectin, BNP, and HbA1c were measured at baseline, 6, and 12 months, and baPWV and mean IMT were measured at baseline and 12 months. Medication adherence was examined using a questionnaire at 6 months.

Results: MDA-LDL was decreased significantly. LDL-C, TG, and Cr were significantly decreased at 6 and 12 months compared with baseline. eGFR was increased at 6 months, and urinary albumin/creatinine ratio was decreased at 12 months. BNP was decreased at 6 and 12 months, and adiponectin was increased at 12 months. Both mean IMT and baPWV were significantly decreased. The results of the questionnaire showed that 93% of patients were satisfied with this medication. No severe adverse event was observed.

Conclusion: This combination tablet controlled both hypertension and dyslipidemia well in type 2 diabetic patients. The deceases in mean IMT and baPWV might suggest the improvement of atherosclerosis by this medication, which could be caused by the reduction of oxidative stress measured by MDA-LDL. In addition, this medication is expected to improve medication adherence.

Keywords: Amlodipine; Atherosclerosis; Atorvastatin; Combination tablet; Diabetes mellitus; Dyslipidemia; Hypertension; Malondialdehyde-modified low-density lipoprotein; Medication adherence; Oxidative stress.