Abstract
We investigated sequential episodes of acute norovirus gastroenteritis in a young child within an 11-month period. The infections were caused by 2 distinct genotypes (GII.4 and GII.6). Failure to achieve cross-protective immunity was linked to absence of an enduring and cross-reactive mucosal immune response, a critical consideration for vaccine design.
Keywords:
Norovirus; diarrhea; genotype; immunity; viruses.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
MeSH terms
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Antibodies, Viral / blood*
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Caliciviridae Infections / diagnosis
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Caliciviridae Infections / immunology
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Caliciviridae Infections / virology*
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Child, Preschool
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Feces / virology
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Female
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Gastroenteritis / diagnosis
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Gastroenteritis / immunology
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Gastroenteritis / virology*
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Genotype
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Humans
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Immunity, Mucosal
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Immunoglobulin A / blood
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Infant
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Norovirus / classification
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Norovirus / genetics*
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Norovirus / immunology*
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Norovirus / isolation & purification
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Phylogeny
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RNA, Viral / genetics
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Viral Structural Proteins / genetics*
Substances
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Antibodies, Viral
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Immunoglobulin A
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RNA, Viral
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Viral Structural Proteins