Sequential gastroenteritis episodes caused by 2 norovirus genotypes

Emerg Infect Dis. 2014 Jun;20(6):1016-8. doi: 10.3201/eid2006.131627.

Abstract

We investigated sequential episodes of acute norovirus gastroenteritis in a young child within an 11-month period. The infections were caused by 2 distinct genotypes (GII.4 and GII.6). Failure to achieve cross-protective immunity was linked to absence of an enduring and cross-reactive mucosal immune response, a critical consideration for vaccine design.

Keywords: Norovirus; diarrhea; genotype; immunity; viruses.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Antibodies, Viral / blood*
  • Caliciviridae Infections / diagnosis
  • Caliciviridae Infections / immunology
  • Caliciviridae Infections / virology*
  • Child, Preschool
  • Feces / virology
  • Female
  • Gastroenteritis / diagnosis
  • Gastroenteritis / immunology
  • Gastroenteritis / virology*
  • Genotype
  • Humans
  • Immunity, Mucosal
  • Immunoglobulin A / blood
  • Infant
  • Norovirus / classification
  • Norovirus / genetics*
  • Norovirus / immunology*
  • Norovirus / isolation & purification
  • Phylogeny
  • RNA, Viral / genetics
  • Viral Structural Proteins / genetics*

Substances

  • Antibodies, Viral
  • Immunoglobulin A
  • RNA, Viral
  • Viral Structural Proteins