Determination of serotonin on platinum electrode modified with carbon nanotubes/polypyrrole/silver nanoparticles nanohybrid

Mater Sci Eng C Mater Biol Appl. 2014 Jul 1:40:49-54. doi: 10.1016/j.msec.2014.03.030. Epub 2014 Mar 25.

Abstract

A new sensor has been developed by a simple electrodeposition of multi-walled carbon nanotubes (MWCNT), polypyrrole (PPy) and colloidal silver nanoparticles on the platinum (Pt) electrode surface. The Pt/MWCNT/PPy/AgNPs electrode was applied to the detection of serotonin in plasmatic serum samples using differential pulse voltammetry (DPV). The synergistic effect of MWCNT/PPy/AgNPs nanohybrid formed yielded a LOD of 0.15 μmol L(-1) (26.4 μg L(-1)). Reproducibility and repeatability values of 2.2% and 1.7%, respectively, were obtained compared to the conventional procedure. The proposed electrode can be an effective material to be used in biological analysis.

Keywords: Carbon nanotubes; Nanohybrid; Polypyrrole; Serotonin; Silver nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascorbic Acid / chemistry
  • Electrochemical Techniques*
  • Electrodes
  • Humans
  • Hydrogen-Ion Concentration
  • Metal Nanoparticles / chemistry
  • Nanostructures / chemistry*
  • Nanotubes, Carbon / chemistry
  • Oxidation-Reduction
  • Polymers / chemistry
  • Pyrroles / chemistry
  • Serotonin / analysis*
  • Serotonin / blood
  • Silver / chemistry
  • Uric Acid / chemistry

Substances

  • Nanotubes, Carbon
  • Polymers
  • Pyrroles
  • Uric Acid
  • polypyrrole
  • Serotonin
  • Silver
  • Ascorbic Acid