Targeting cytotoxicity and tubulin polymerization by metal-carbene complexes on a purine tautomer platform

Dalton Trans. 2014 Jul 14;43(26):9838-42. doi: 10.1039/c4dt00529e. Epub 2014 May 23.

Abstract

This communication describes the synthesis, structural investigation and tubulin binding of purine rare imino-tautomer based Ag(i) and Hg(ii)-carbene complexes. These complexes exhibit cytotoxicity through tubulin interaction by binding to a site close to the GTP binding site.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives
  • Adenine / chemistry
  • Cell Line, Tumor
  • Cell Survival
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • Humans
  • Mercury / chemistry
  • Mercury / pharmacology*
  • Methane / analogs & derivatives*
  • Methane / chemistry
  • Methane / pharmacology
  • Polymerization
  • Silver / chemistry
  • Silver / pharmacology*
  • Tubulin / metabolism*
  • Tubulin Modulators / chemistry
  • Tubulin Modulators / pharmacology*

Substances

  • Coordination Complexes
  • Tubulin
  • Tubulin Modulators
  • carbene
  • Silver
  • Mercury
  • Adenine
  • Methane