Abstract
This communication describes the synthesis, structural investigation and tubulin binding of purine rare imino-tautomer based Ag(i) and Hg(ii)-carbene complexes. These complexes exhibit cytotoxicity through tubulin interaction by binding to a site close to the GTP binding site.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine / analogs & derivatives
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Adenine / chemistry
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Cell Line, Tumor
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Cell Survival
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Humans
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Mercury / chemistry
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Mercury / pharmacology*
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Methane / analogs & derivatives*
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Methane / chemistry
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Methane / pharmacology
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Polymerization
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Silver / chemistry
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Silver / pharmacology*
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Tubulin / metabolism*
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Tubulin Modulators / chemistry
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Tubulin Modulators / pharmacology*
Substances
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Coordination Complexes
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Tubulin
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Tubulin Modulators
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carbene
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Silver
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Mercury
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Adenine
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Methane