Abstract
A new diarylpropanoid, horsfiequinone A (1), and five new dimeric diarylpropanoids with 1,4-p-benzoquinone residue, horsfiequinones B-F (2-6), along with a known compound, combrequinone B (7), were isolated from Horsfieldia tetratepala. Their structures were elucidated by means of spectroscopic analysis. Horsfiequinones B-F (2-6), isolated as enantiomer mixtures with unequal proportions, were verified by analysis on a chiral OD-H HPLC column. Cytotoxicity evaluation against five human tumor lines showed selective inhibitory effects on HL-60 for several compounds tested with IC50 values ranging from 3.18 ± 0.67 to 6.61 ± 0.08 µM.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzoquinones / chemistry
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Benzoquinones / isolation & purification*
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Benzoquinones / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Myristicaceae / chemistry*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Propanols / chemistry
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Propanols / isolation & purification*
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Propanols / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Benzoquinones
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Plant Extracts
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Propanols
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quinone