FDG-PET/CT is a pivotal imaging modality to diagnose rare intravascular large B-cell lymphoma: case report and review of literature

Cecile Colavolpe; Mikael Ebbo; Delphine Trousse; Hajar Khibri; Jerome Franques; Bruno Chetaille; Diane Coso; Matthieu John Ouvrier; Lauris Gastaud; Eric Guedj; Nicolas Schleinitz

doi:10.1002/hon.2140

FDG-PET/CT is a pivotal imaging modality to diagnose rare intravascular large B-cell lymphoma: case report and review of literature

Hematol Oncol. 2015 Jun;33(2):99-109. doi: 10.1002/hon.2140. Epub 2014 May 21.

Authors

Affiliations

¹ Department of Nuclear Medicine, CHU Timone, Marseille, France.
² Department of Internal Medicine, CHU Conception, Marseille, France.
³ Department of Thoracic Surgery, CHU Nord, Marseille, France.
⁴ Department of Neurology, CHU Timone, Marseille, France.
⁵ Department of Bio-pathology, Institut Paoli-Calmettes, Marseille, France.
⁶ Department of Onco-hematology, Institut Paoli-Calmettes, Marseille, France.
⁷ Department of Nuclear Medicine, Centre Antoine Lacassagne, Nice, France.
⁸ Department of Medical Oncology, Centre Antoine Lacassagne, Nice, France.

PMID: 24850057
DOI: 10.1002/hon.2140

Abstract

Intravascular large B-cell lymphoma (IVLBCL) remains a diagnostic challenge, because of non-specific findings on clinical, laboratory, and imaging studies. We present a case in which 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography was particularly useful to suspect the diagnosis, to detect unexpected locations, to guide contributive biopsy, and to assess the response to treatment. In case of initial negative results, FDG-PET should be repeated in the course of clinical evolution. In the presence of neurological or hormonal symptoms without brain magnetic resonance imaging abnormality, FDG-PET brain slices could depict additional pituitary and/or brain hypermetabolisms. We discuss the potential interests of FDG-PET in IVLBCL by a literature review.

Keywords: FDG-PET/CT; intravascular diffuse large B-cell lymphoma; lung biopsy.

Publication types

Case Reports
Review

MeSH terms

Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Brain / diagnostic imaging
Brain / metabolism
Cough / etiology
Disease Progression
Fluorine Radioisotopes / pharmacokinetics
Fluorodeoxyglucose F18 / pharmacokinetics
Hematopoietic Stem Cell Transplantation
Humans
Lung / diagnostic imaging
Lung / metabolism
Lymphoma, Large B-Cell, Diffuse / diagnosis*
Lymphoma, Large B-Cell, Diffuse / diagnostic imaging
Lymphoma, Large B-Cell, Diffuse / drug therapy
Lymphoma, Large B-Cell, Diffuse / therapy
Male
Multimodal Imaging*
Positron-Emission Tomography*
Radiopharmaceuticals / pharmacokinetics
Remission Induction
Thyroid Gland / diagnostic imaging
Thyroid Gland / metabolism
Tissue Distribution
Tomography, X-Ray Computed*
Transplantation, Autologous
Vascular Neoplasms / diagnosis*
Vascular Neoplasms / diagnostic imaging
Vascular Neoplasms / drug therapy
Vascular Neoplasms / therapy

Substances

Fluorine Radioisotopes
Radiopharmaceuticals
Fluorodeoxyglucose F18