Dissolvable metallohydrogels for controlled release: evidence of a kinetic supramolecular gel phase intermediate

Chem Commun (Camb). 2014 Jul 7;50(53):7032-5. doi: 10.1039/c4cc02771j. Epub 2014 May 21.

Abstract

Two metallohydrogels based on an amino acid-based ligand and Zn(II) salts were synthesized. These hydrogels show an uncommon, reversible, time-dependent transformation from the opaque to transparent state. These hydrogels also exhibit gradual dissolution in water (pH ≤ 7) over time. A water-soluble stimulant, caffeine, could be in situ loaded into the hydrogels and slowly released during dissolution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Caffeine / administration & dosage
  • Caffeine / chemistry
  • Central Nervous System Stimulants / administration & dosage
  • Central Nervous System Stimulants / chemistry
  • Delayed-Action Preparations
  • Drug Stability
  • Hydrogels / chemistry*
  • Kinetics
  • Ligands
  • Metals / chemistry*
  • Solubility
  • Zinc / chemistry

Substances

  • Amino Acids
  • Central Nervous System Stimulants
  • Delayed-Action Preparations
  • Hydrogels
  • Ligands
  • Metals
  • Caffeine
  • Zinc