Abstract
Two metallohydrogels based on an amino acid-based ligand and Zn(II) salts were synthesized. These hydrogels show an uncommon, reversible, time-dependent transformation from the opaque to transparent state. These hydrogels also exhibit gradual dissolution in water (pH ≤ 7) over time. A water-soluble stimulant, caffeine, could be in situ loaded into the hydrogels and slowly released during dissolution.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry
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Caffeine / administration & dosage
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Caffeine / chemistry
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Central Nervous System Stimulants / administration & dosage
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Central Nervous System Stimulants / chemistry
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Delayed-Action Preparations
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Drug Stability
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Hydrogels / chemistry*
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Kinetics
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Ligands
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Metals / chemistry*
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Solubility
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Zinc / chemistry
Substances
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Amino Acids
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Central Nervous System Stimulants
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Delayed-Action Preparations
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Hydrogels
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Ligands
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Metals
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Caffeine
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Zinc