slanDCs in carcinoma-draining lymph nodes

William Vermi; Silvia Lonardi; Mattia Bugatti; Federica Calzetti; Alessandra Micheletti; Marco A Cassatella

doi:10.4161/onci.28246

slanDCs in carcinoma-draining lymph nodes

Oncoimmunology. 2014 Jan 1;3(3):e28246. doi: 10.4161/onci.28246. Epub 2014 Mar 17.

Authors

William Vermi¹, Silvia Lonardi², Mattia Bugatti², Federica Calzetti³, Alessandra Micheletti³, Marco A Cassatella³

Affiliations

¹ Department of Molecular and Translational Medicine; Section of Pathology; University of Brescia; Brescia, Italy ; Department of Pathology and Immunology; Washington University School of Medicine; Saint Louis, MO USA.
² Department of Molecular and Translational Medicine; Section of Pathology; University of Brescia; Brescia, Italy.
³ Department of Pathology and Diagnostics; Section of General Pathology; University of Verona; Verona, Italy.

Abstract

Dendritic cells (DCs) are known to initiate adaptive immune responses against malignant cells. However, the role in anticancer immunosurveillance of 6-sulfo LacNAc-expressing DCs (slanDCs), a distinct population of circulating and tissue-resident pro-inflammatory DCs, is unclear. We have recently demonstrated the involvement of slanDCs in nodal immune responses against carcinoma cells.

Keywords: carcinoma; slanDCs; tumor-draining lymph nodes.