Mitophagy mechanisms and role in human diseases

Int J Biochem Cell Biol. 2014 Aug:53:127-33. doi: 10.1016/j.biocel.2014.05.010. Epub 2014 May 16.

Abstract

Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy activities. This review will highlight recent studies that have identified mediators of mitophagy in response to starvation, loss of mitochondrial membrane potential or perturbation of mitochondrial integrity. Furthermore, we will review evidence of mitophagy dysfunction in various human diseases and discuss the potential for therapeutic interventions that target mitophagy processes.

Keywords: Cancer; Heart disease; Mitochondria; Mitophagy; Parkinson's disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Heart Diseases / genetics*
  • Heart Diseases / metabolism
  • Heart Diseases / pathology
  • Humans
  • Membrane Potential, Mitochondrial
  • Mitophagy / genetics*
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Parkinson Disease / genetics*
  • Parkinson Disease / metabolism
  • Parkinson Disease / pathology