Abstract
We demonstrate that ligand hydrophobicity can be used to increase affinity and selectivity of binding between monolayer-protected cationic gold nanoparticles and β-lactoglobulin protein isoforms containing two amino acid mutations.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding Sites
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Gold / chemistry*
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Hydrophobic and Hydrophilic Interactions
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Lactoglobulins / chemistry*
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Lactoglobulins / genetics
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Lactoglobulins / ultrastructure*
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Materials Testing
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Metal Nanoparticles / chemistry*
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Metal Nanoparticles / ultrastructure
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Mutagenesis, Site-Directed
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Nanocomposites / chemistry*
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Nanocomposites / ultrastructure
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Particle Size
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Protein Binding
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Protein Isoforms / chemistry
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Protein Isoforms / ultrastructure
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Structure-Activity Relationship
Substances
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Lactoglobulins
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Protein Isoforms
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Gold