A model study for tethering of (bio)active molecules to biomaterial surfaces through arginine

Org Biomol Chem. 2014 Jun 28;12(24):4089-92. doi: 10.1039/c4ob00160e.

Abstract

A new approach for tethering of bioactive molecules via arginine is proposed and validated on collagen 2D matrices. The method involves the introduction of a methyl ketone on arginine side-chains, followed by reaction with model alkoxyamino derivatives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arginine / chemistry*
  • Biocompatible Materials / chemistry*
  • Collagen / chemistry*
  • Guanidine / chemistry
  • Horses
  • Ketones / chemistry
  • Lactose / chemistry
  • Pyruvaldehyde / chemistry
  • Spectrometry, Fluorescence
  • Spectroscopy, Fourier Transform Infrared
  • Surface Properties

Substances

  • Biocompatible Materials
  • Ketones
  • Pyruvaldehyde
  • Collagen
  • Arginine
  • Lactose
  • Guanidine