Multifunctional theranostic red blood cells for magnetic-field-enhanced in vivo combination therapy of cancer

Adv Mater. 2014 Jul 23;26(28):4794-802. doi: 10.1002/adma.201400158. Epub 2014 May 19.

Abstract

Red blood cells are attached to iron oxide nanoparticles pre-coated with chlorine e6, a photosensitizer, and then loaded with a chemotherapeutic drug, doxorubicin, to enable imaging-guided combined photodynamic and chemotherapy of cancer, achieving excellent synergistic therapeutic effects in an animal tumor model. This work highlights the great promise of integrating cell-based drug-delivery systems with nanotechnology as a biocompatible multifunctional platform for applications in cancer theranostics.

Keywords: biomaterials; combination therapy; drug delivery; magnetic targeting; red blood cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / therapy*
  • Cell Line, Tumor
  • Cell Tracking / methods
  • Chlorophyllides
  • Combined Modality Therapy / methods
  • Doxorubicin / administration & dosage*
  • Erythrocyte Transfusion / methods*
  • Erythrocytes / chemistry
  • Erythrocytes / cytology
  • Magnetic Resonance Imaging, Interventional / methods
  • Magnetite Nanoparticles / therapeutic use*
  • Mice
  • Mice, Inbred BALB C
  • Phototherapy / methods
  • Porphyrins / administration & dosage*
  • Porphyrins / chemistry

Substances

  • Chlorophyllides
  • Magnetite Nanoparticles
  • Porphyrins
  • phytochlorin
  • Doxorubicin