Association of IL6 single nucleotide polymorphisms with febrile seizures

Amin Shahrokhi; Ameneh Zare-Shahabadi; Samaneh Soltani; Mahmoud Reza Ashrafi; Samaneh Zoghi; Seyed Ahmad Hosseini; Moreteza Heidari; Bahareh Yaghmaei; Babak Pourakbari; Nima Rezaei

doi:10.1016/j.jns.2014.04.003

Association of IL6 single nucleotide polymorphisms with febrile seizures

J Neurol Sci. 2014 Jul 15;342(1-2):25-8. doi: 10.1016/j.jns.2014.04.003. Epub 2014 Apr 13.

Authors

Affiliations

¹ Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
² Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
³ Molecular Immunology Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
⁴ Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Pediatrics Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
⁶ Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Molecular Immunology Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: rezaei_nima@tums.ac.ir.

PMID: 24834995
DOI: 10.1016/j.jns.2014.04.003

Abstract

Febrile seizures (FSs) are the most common convulsive event in children. Inflammatory elements and genetics have major roles in their pathogenesis. As of the importance of interleukin-6 (IL-6) in FS, this study was performed to assess IL6 single nucleotide polymorphisms (SNPs) in a group of patients with FS. IL6 gene (-174 and +565) SNPs were studied on genomic DNAs of 90 children with FS, using PCR-SSP method. The results were compared to 139 healthy individuals. The presence of the G allele or the GG genotype at +565 position reduced risk of FS, while the A allele at +565 position of the promoter regions was a constituted risk factor for developing FS. This study could support the idea that IL6 SNPs play a role in the pathogenesis of FS.

Keywords: Cytokine; Etiology; Febrile seizures; Interleukin-6; Pro-inflammatory; Single nucleotide polymorphisms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Case-Control Studies
Child, Preschool
Female
Genetic Predisposition to Disease / genetics
Genotype
Humans
Infant
Interleukin-6 / genetics*
Male
Polymorphism, Single Nucleotide / genetics*
Promoter Regions, Genetic / genetics
Seizures, Febrile / genetics*

Substances

Interleukin-6