Bacteria exploit platelets

Blood. 2014 May 15;123(20):3067-8. doi: 10.1182/blood-2014-04-565432.

Abstract

In this issue of Blood, Arman et al show that bacteria use immunoglobulin G (IgG) from plasma to engage platelet surface receptors FcγRIIA and integrin αIIbβ3 to induce platelet activation, which is further facilitated by platelet factor 4 (PF4).

Publication types

  • Comment

MeSH terms

  • Animals
  • Blood Platelets / microbiology*
  • Host-Pathogen Interactions*
  • Humans
  • Platelet Factor 4 / immunology*
  • Platelet Glycoprotein GPIIb-IIIa Complex / immunology*
  • Receptors, IgG / immunology*
  • Staphylococcus aureus / physiology*
  • Streptococcus / physiology*

Substances

  • Fc gamma receptor IIA
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Receptors, IgG
  • Platelet Factor 4