Abstract
In this issue of Blood, Arman et al show that bacteria use immunoglobulin G (IgG) from plasma to engage platelet surface receptors FcγRIIA and integrin αIIbβ3 to induce platelet activation, which is further facilitated by platelet factor 4 (PF4).
MeSH terms
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Animals
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Blood Platelets / microbiology*
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Host-Pathogen Interactions*
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Humans
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Platelet Factor 4 / immunology*
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Platelet Glycoprotein GPIIb-IIIa Complex / immunology*
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Receptors, IgG / immunology*
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Staphylococcus aureus / physiology*
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Streptococcus / physiology*
Substances
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Fc gamma receptor IIA
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Platelet Glycoprotein GPIIb-IIIa Complex
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Receptors, IgG
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Platelet Factor 4