Abstract
The NOD-like receptors (NLRs) were among the first innate immune receptors discovered, yet a clear understanding of the basic principles underlying their mechanisms of action is lacking. Two recent studies provide important cell biological insights into the subcellular sites of NOD1- and NOD2-dependent signaling.
Copyright © 2014 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Endosomes / genetics
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Endosomes / metabolism*
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Humans
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Intracellular Membranes / metabolism
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Nod1 Signaling Adaptor Protein / genetics
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Nod1 Signaling Adaptor Protein / metabolism*
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Nod2 Signaling Adaptor Protein / genetics
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Nod2 Signaling Adaptor Protein / metabolism*
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Signal Transduction*
Substances
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Nod1 Signaling Adaptor Protein
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Nod2 Signaling Adaptor Protein