Paravertebral mushroom: identification of a novel species of Phellinus as a human pathogen in chronic granulomatous disease

Suk See De Ravin; Mark Parta; Deanna A Sutton; Brian L Wickes; Elizabeth H Thompson; Nathan P Wiederhold; Karen K Nakasone; Meghna Alimchandani; Amy OConnell; Luigi Notarangelo; Elizabeth Kang; Harry L Malech; Adrian M Zelazny

doi:10.1128/JCM.00667-14

Paravertebral mushroom: identification of a novel species of Phellinus as a human pathogen in chronic granulomatous disease

J Clin Microbiol. 2014 Jul;52(7):2726-9. doi: 10.1128/JCM.00667-14. Epub 2014 May 14.

Affiliations

¹ Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
² Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.
³ Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
⁴ Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
⁵ Center for Forest Mycology Research, Northern Research Station, Forest Products Laboratory, USDA Forest Service, Madison, Wisconsin, USA.
⁶ Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
⁷ Division of Immunology, Boston Children's Hospital, Boston, Massachusetts, USA.
⁸ Department of Laboratory Medicine Clinical Center, National Institutes of Health, Bethesda, Maryland, USA azelazny@mail.nih.gov.

Abstract

We describe a case of paravertebral abscess caused by a Phellinus sp. in a boy with chronic granulomatous disease. Sequence-based identification of this mold, a new agent of disease, suggests a close relation to Phellinus umbrinellus.

Publication types

Case Reports
Research Support, N.I.H., Intramural

MeSH terms

Abscess / diagnosis*
Abscess / microbiology*
Abscess / pathology
Antifungal Agents / pharmacology
Basidiomycota / classification
Basidiomycota / drug effects
Basidiomycota / genetics
Basidiomycota / isolation & purification*
Child
Cluster Analysis
DNA, Fungal / chemistry
DNA, Fungal / genetics
DNA, Ribosomal / chemistry
DNA, Ribosomal / genetics
DNA, Ribosomal Spacer / chemistry
DNA, Ribosomal Spacer / genetics
Genes, rRNA
Granulomatous Disease, Chronic / complications*
Humans
Male
Microbial Sensitivity Tests
Molecular Sequence Data
Mycoses / diagnosis*
Mycoses / microbiology*
Mycoses / pathology
Phylogeny
RNA, Fungal / genetics
RNA, Ribosomal / genetics
Radiography, Abdominal
Radiography, Thoracic
Sequence Analysis, DNA
Tomography, X-Ray Computed

Substances

Antifungal Agents
DNA, Fungal
DNA, Ribosomal
DNA, Ribosomal Spacer
RNA, Fungal
RNA, Ribosomal
RNA, ribosomal, 26S

Associated data

GENBANK/KF757337
GENBANK/KF757338

Grants and funding

Intramural NIH HHS/United States