A coralline algal-associated bacterium, pseudoalteromonas strain J010, yields five new korormicins and a bromopyrrole

Mar Drugs. 2014 May 13;12(5):2802-15. doi: 10.3390/md12052802.

Abstract

The ethanol extract of Pseudoalteromonas strain J010, isolated from the surface of the crustose coralline alga Neogoniolithon fosliei, yielded thirteen natural products. These included a new bromopyrrole, 4'-((3,4,5-tribromo-1H-pyrrol-2-yl) methyl)phenol (1) and five new korormicins G-K (2-6). Also isolated was the known inducer of coral larval metamorphosis, tetrabromopyrrole (TBP), five known korormicins (A-E, previously named 1, 1a-c and 3) and bromoalterochromide A (BAC-A). Structures of the new compounds were elucidated through interpretation of spectra obtained after extensive NMR and MS investigations and comparison with literature values. The antibacterial, antifungal and antiprotozoal potential of 1-6, TBP and BAC-A was assessed. Compounds 1-6 showed antibacterial activity while BAC-A exhibited antiprotozoal properties against Tetrahymena pyriformis. TBP was found to have broad-spectrum activity against all bacteria, the protozoan and the fungus Candida albicans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / microbiology*
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / pharmacology
  • Antiprotozoal Agents / pharmacology
  • Fatty Acids, Unsaturated / chemistry
  • Fatty Acids, Unsaturated / isolation & purification
  • Fatty Acids, Unsaturated / pharmacology
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Lactones / pharmacology
  • Microbial Sensitivity Tests
  • Pseudoalteromonas / chemistry*
  • Pyrroles / chemistry*
  • Pyrroles / isolation & purification
  • Pyrroles / pharmacology
  • Rhodophyta / chemistry*
  • Tetrahymena pyriformis / drug effects

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Antiprotozoal Agents
  • Fatty Acids, Unsaturated
  • Lactones
  • Pyrroles
  • korormicin