Reining in radiation injury: HIF2α in the gut

Chang-Lung Lee; Everett J Moding; David G Kirsch

doi:10.1126/scitranslmed.3009155

Reining in radiation injury: HIF2α in the gut

Sci Transl Med. 2014 May 14;6(236):236fs20. doi: 10.1126/scitranslmed.3009155.

Authors

Chang-Lung Lee¹, Everett J Moding², David G Kirsch³

Affiliations

¹ Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
² Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
³ Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. david.kirsch@duke.edu.

PMID: 24828075
DOI: 10.1126/scitranslmed.3009155

Abstract

Deletion of prolyl hydroxylase domain proteins or overexpression of hypoxia-inducible factor 2α (HIF2α) in the gastrointestinal epithelium improves survival of mice after abdominal irradiation (Taniguchi et al., this issue).

Publication types

Comment

MeSH terms

Animals
Basic Helix-Loop-Helix Transcription Factors / chemistry*
Basic Helix-Loop-Helix Transcription Factors / genetics*
Humans
Radiation Injuries / drug therapy*

Substances

Basic Helix-Loop-Helix Transcription Factors
endothelial PAS domain-containing protein 1