Abstract
Human leukocyte antigen-G (HLA-G) is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Exosomes / immunology
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Gene Expression Regulation
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HLA-G Antigens / chemistry*
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HLA-G Antigens / genetics
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HLA-G Antigens / immunology
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Humans
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Membrane Proteins / chemistry*
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Membrane Proteins / genetics
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Membrane Proteins / immunology
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Promoter Regions, Genetic
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Protein Isoforms / chemistry
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Protein Isoforms / genetics
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Protein Isoforms / immunology
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Protein Multimerization
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Protein Processing, Post-Translational*
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Protein Structure, Tertiary
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Receptors, Immunologic / genetics
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Receptors, Immunologic / immunology
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Solubility
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Ubiquitination
Substances
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HLA-G Antigens
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Membrane Proteins
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Protein Isoforms
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Receptors, Immunologic