Facile fabrication of uniform hollow silica microspheres using a novel biological template

Alireza Ebrahiminezhad; Sohrab Najafipour; Amin Kouhpayeh; Aydin Berenjian; Sara Rasoul-Amini; Younes Ghasemi

doi:10.1016/j.colsurfb.2014.03.052

Facile fabrication of uniform hollow silica microspheres using a novel biological template

Colloids Surf B Biointerfaces. 2014 Jun 1:118:249-53. doi: 10.1016/j.colsurfb.2014.03.052. Epub 2014 Apr 6.

Authors

Alireza Ebrahiminezhad¹, Sohrab Najafipour², Amin Kouhpayeh³, Aydin Berenjian⁴, Sara Rasoul-Amini⁵, Younes Ghasemi⁶

Affiliations

¹ Department of Biotechnology, Fasa University of Medical Sciences, Fasa, Iran; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
² Department of Microbiology, Fasa University of Medical Sciences, Fasa, Iran.
³ Department of Pharmacology, Fasa University of Medical Sciences, Fasa, Iran.
⁴ Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
⁵ Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
⁶ Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: Ghasemiy@sums.ac.ir.

PMID: 24811795
DOI: 10.1016/j.colsurfb.2014.03.052

Abstract

Biological templates, due to their ease of preparation and surface modifications can be a promising approach to fabricate hollow structures. In this study, for the first time, a biological template was used for the production of hollow silica microspheres. Silica was successfully deposited on Staphylococcus aureus cells surface using the Stöber method. The hollow silica spheres with a mesoporous shell of approximately 700nm in diameter were produced by applying this novel method.

Keywords: Bacterial template; Mesoporous silica; Staphylococcus aureus; Stöber method; Tetraethyl orthosilicate (TEOS).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adsorption
Microscopy, Electron, Transmission
Microspheres*
Nitrogen
Silicon Dioxide / chemistry*
Spectroscopy, Fourier Transform Infrared
Staphylococcus aureus / cytology*
Staphylococcus aureus / ultrastructure
Temperature

Substances

Silicon Dioxide
Nitrogen