Macro and small over micro: macromolecules and small molecules that regulate microRNAs

Soowon Kang; Kyungtaek Im; Jihae Baek; Sungroh Yoon; Hyeyoung Min

doi:10.1002/cbic.201402007

Macro and small over micro: macromolecules and small molecules that regulate microRNAs

Chembiochem. 2014 May 26;15(8):1071-8. doi: 10.1002/cbic.201402007. Epub 2014 May 2.

Authors

Soowon Kang¹, Kyungtaek Im, Jihae Baek, Sungroh Yoon, Hyeyoung Min

Affiliation

¹ Department of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 156-756 (Korea).

PMID: 24797338
DOI: 10.1002/cbic.201402007

Abstract

Given the correlation between the deregulation of specific miRNAs and disease onset, it is critical to identify miRNA regulators that effectively control miRNAs involved in the pathogenesis of target diseases. This review provides the latest update on oligonucleotide- and small-molecule-based miRNA regulators, and discusses assays developed to screen for small-molecule regulators.

Keywords: RNA; high-throughput screening; microRNAs; regulators; small molecules.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomimetic Materials / chemistry
Biomimetic Materials / pharmacology
Humans
Macromolecular Substances / chemistry
Macromolecular Substances / pharmacology*
MicroRNAs / antagonists & inhibitors*
MicroRNAs / biosynthesis
MicroRNAs / genetics
MicroRNAs / metabolism*
Oligonucleotides, Antisense / genetics
Oligonucleotides, Antisense / pharmacology*
Reproducibility of Results
Small Molecule Libraries / chemistry
Small Molecule Libraries / pharmacology*
Substrate Specificity

Substances

Macromolecular Substances
MicroRNAs
Oligonucleotides, Antisense
Small Molecule Libraries