Aim: The aim of this article was to investigate the performance and predictive value of urinary liver-type FABP (uL-FABP) and urinary NGAL (uNGAL) for renal function and prognosis in obstructive nephropathy (ON).
Patients & methods: A total of 108 ON patients and urine samples were collected. An ELISA was used to determine the uL-FABP and uNGAL levels. A total of 90 patients completed the 1-year follow-up and were used to evaluate the predictive value of uL-FABP and uNGAL for the renal prognosis in ON.
Results: During the 1-year renal function follow-up, the uL-FABP level was significantly correlated with poor prognosis. When the preoperative uL-FABP and uNGAL or 72-h postoperative uL-FABP and uNGAL levels were combined, the areas under the curve for renal prognosis were 0.968 and 0.952, respectively.
Conclusion: uL-FABP was helpful for the prediction of renal prognosis in ON. The combination of uL-FABP and uNGAL increased the accuracy of prediction.