Aging stem cells: transcriptome meets epigenome meets methylome

Stefan Tümpel; K Lenhard Rudolph

doi:10.1016/j.stem.2014.04.013

Aging stem cells: transcriptome meets epigenome meets methylome

Cell Stem Cell. 2014 May 1;14(5):551-2. doi: 10.1016/j.stem.2014.04.013.

Authors

Stefan Tümpel¹, K Lenhard Rudolph²

Affiliations

¹ Leibniz Institute for Age Research, Fritz Lipmann Institute, D-07745 Jena, Germany.
² Leibniz Institute for Age Research, Fritz Lipmann Institute, D-07745 Jena, Germany. Electronic address: klrudolph@fli-leibniz.de.

PMID: 24792109
DOI: 10.1016/j.stem.2014.04.013

Abstract

Aging is associated with impairments in hematopoietic stem cell (HSC) function and an increased risk of leukemogenesis. In this issue of Cell Stem Cell, Sun et al. (2014) use highly purified HSCs along with an integrated genomic approach to evaluate aging-associated alterations in the epigenome and transcriptome of HSCs.

Publication types

Comment

MeSH terms

Animals
Epigenomics / methods*
Hematopoietic Stem Cells / cytology*
Hematopoietic Stem Cells / metabolism*
Male