LL37 peptide@silver nanoparticles: combining the best of the two worlds for skin infection control

Nanoscale. 2014 Jun 7;6(11):5725-8. doi: 10.1039/c4nr01284d. Epub 2014 May 2.

Abstract

Capping silver nanoparticles with LL37 peptide eradicates the antiproliferative effect of silver on primary skin cells, but retains the bactericidal properties of silver nanoparticles with activities comparable to silver nitrate or silver sulfadiazine. In addition, LL37 capped silver nanoparticles have anti-biofilm formation activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimicrobial Cationic Peptides
  • Cathelicidins / chemistry*
  • Cathelicidins / pharmacology
  • Cell Line
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Humans
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / toxicity
  • Microbial Sensitivity Tests
  • Silver / chemistry*
  • Skin / cytology
  • Skin / microbiology
  • Ultraviolet Rays

Substances

  • Antimicrobial Cationic Peptides
  • Cathelicidins
  • Silver